Among the more than 1,000 artists who participated in Plexus events from 1983 to 2024, the following artists had a significant influence as key players in the Plexus art journey. They are listed by the year they began contributing to the Plexus voyage:

• Sandro Dernini – A Sardinian biologist, cultural organizer, and artist. As a co-founder of Plexus in 1982 in New York, he was instrumental in developing its vision and organizing its events.

• Giancarlo Schiaffini – A prominent Italian contemporary musician and composer who played a crucial role from 1981-82 in New York in developing the seminal idea of Plexus as an open multi-art form.

• Willem Brugman – A Dutch actor and theatre director who contributed significantly from 1984 in New York, developing the concept of modular construction within Plexus as a participatory process that merges diverse art forms without a hierarchical structure.

• Mitch Ross – An American comedian and comic designer who was a key figure in the Plexus voyage starting in 1983 as the master of ceremonies at the Plexus performance space in New York.

• Miguel Algarin – An influential American poet and founder of the Nuyorican Poets Café. He embodied, since 1984 in New York, the aesthetic values of Plexus as a means to address human issues, until his death in 2020.

• William Parker – A prominent American jazz musician and composer who influenced the development of Plexus through his 1984 Open Call In Order to Survive, aimed at enhancing independent productions and supporting local artists.

• Bruce Richard Nuggent – An American artist and contributor to the African-American literary magazine Fire!!, pivotal since 1984 in New York in developing the Plexus vision as not for propaganda. He was celebrated in 1986 as the first honorary Plexus chairman; he died in the early 1990s.

• Alfa Diallo – A Senegalese poet who was instrumental since 1984 in New York, contributing to the Plexus vision with his poem "One on One" and his poetry collection "Still a Prisoner," until his passing in 2022.

• Stephen Di Lauro – An American playwright, musician, and poet who significantly contributed since 1984 in the Lower East Side by adding a theatrical dimension to the Plexus Nuraghic Voyage.

• David Boyle – An American community activist who emphasized the importance of collaborative art projects and community engagement since 1985 in the Lower East Side of New York, embodying the inclusive spirit of Plexus.

• Rolando Politi – An American community activist who contributed since 1985 in New York, focusing on community empowerment through arts.

• Lynne Kanter – An American photographer who captured Plexus art moments starting in 1984 in New York, famously taking "photos in the photos."

• Butch Morris – A prominent American jazz musician and conductor who played an essential role from 1985-86 in New York in developing the concept of the art opera as a multi-arts format based on improvised interactions among artists. He passed away in 2013.

• Paolo Maltese – An Italian historian who bridged history and economics within Plexus art operas since 1985 in Paris and Milan, contributing until his death in 2000.

• Eve Vaterlaus – An American visual artist who provided insights into the creative process underlying the Plexus art initiatives since 1985 in New York.

• Leonard Horowitz – An American art critic who developed the idea of "compressionism" in 1986 in New York, emphasizing the diminishing time for aesthetic distance between the artist and observer, creating a new operatic form. He passed away in the 1990s.

• Arturo Lindsay – An American visual artist and performer who played a vital role as an ancestral messenger in the Plexus journey since 1986 in New York, known for his ritual art performances.

• George Chaikin – An American computer scientist who contributed since 1986 in New York by fostering experimental exchanges between art and technology to raise consciousness and community participation. He died in 2007.

• Joanne Freedom – An American community activist and co-founder of the Rainbow Family of the United States. She played a significant role since 1986 in New York in fostering community wellness within the Plexus.

• Garrick Beck – An American community activist and co-founder of the Rainbow Family who contributed since 1986 in New York to community-building efforts in Plexus initiatives.

• Langouste MBow – A Senegalese actor and visual artist who embodied animist spiritual freedom within Plexus since 1986 in Dakar, until his death in 1990.

• Kre MBaye – A prominent Senegalese visual artist who played a crucial role in embodying animist spiritual freedom within Plexus since 1986 in Dakar. He was a charismatic figure in the art journey until his death in 2014.

• Gianni Villella – An Italian sociologist who focused on social responsibility within Plexus since 1986 in Rome and Dakar, enriching the collective’s artistic endeavors until his death in 2018.

• Gaetano Brundu – A Sardinian visual artist who contributed to the Plexus vision by emphasizing contemporary art freedom since 1986 in Cagliari, until his death in 2015.

• Carlo Antonio “Cicci” Borghi – A Sardinian performer and visual artist who was essential to the Plexus voyage since 1986 in Cagliari, promoting art freedom outside conventional schemes.

• Franco Meloni – A Sardinian physics professor who contributed significantly to blending art and science within Plexus since 1987 in Cagliari, engaging both artistic and scientific communities in contemporary dialogues.

• Stefano Asili – A Sardinian graphic designer who played a key role in the Plexus voyage since 1987 in Cagliari, contributing to creative cultural navigations until his passing in 2021.

• Luigi Mazzarelli – A Sardinian visual artist who emphasized the challenges of balancing freedom in artistic activities with organizational structures within Plexus since 1988 in Cagliari. He passed away in 2006.

• Anna Saba – An Italian visual artist who contributed since 1987 in Cagliari by creating original art books that illustrate the Plexus art journey.

• Fabrizio Bertuccioli – An Italian visual artist who embodied the freedom of art within the Plexus vision since 1987 in Rome, enhancing perception and awareness of contemporary reality.

• Micaela Serino – An Italian visual artist active since 1987 in Rome, known for creating original Plexus art money and designing numerous communication materials.

• Andrea Portas – A Sardinian visual artist and performer who has actively participated since 1987 in Cagliari, challenging the operational status quo of Plexus.

• Assane MBaye – A Senegalese artist and organizer who played a vital role since 1987 in organizing three Triangle de Art Festivals as part of the DakOff of the Biennale of Contemporary African Art in Dakar. He passed away in 2017.

• Youssouph Traore – A Senegalese intellectual who served as president of the Club Literaire David Diop since 1987 in Dakar, contributing substantially to the Plexus journey until his death in 2009.

• Jose Rodriguez – An American community activist who emphasized community engagement through creative expressions since 1988 in the Lower East Side of New York, enhancing the Plexus vision.

• David W. Ecker – An American art education scholar who played a significant role since 1990 at New York University, and as chair of the International Society for the Advancement of Living Traditions in Arts, advocating for the role of the artist as a researcher in preserving living traditions in the community. He passed away in 2013.

• Frans Evers – A Dutch psychologist who contributed since 1990 in Amsterdam, integrating the concept of synesthesia into the Plexus vision until his passing in 2010.

• Seni MBaye – A Senegalese visual artist who significantly contributed to Plexus since 2002 in Dakar by creating historical affiches for the Plexus Art Slavery Manifesto and organizing events at his studio in the Village of Arts during the DakOff of the Biennale of Contemporary African Art. He died in 2019.

• Alessandra Menesini – A Sardinian art critic who has played a key role since 1993 in Cagliari, providing insightful texts for a deeper understanding of the Plexus dream.

• Luisa Mazzullo – An Italian visual artist who contributed since 2002 in Rome, creating from 2004-2006 the Plexus Erosions and Renaissance shows artwork affiches, and enhancing more understanding of Plexus' creative value.

• Raffaello Paiella – An Italian visual artist and art critic who joined the Plexus journey in 1996, contributing significantly to its artistic narrative.

• Giorgio Fiume – An Italian performer and visual artist who has actively participated since 1996 in Rome, playing a significant role in the Plexus art journey.

• Glaucia Coelho Demenjour - A Brasilian visual artist. She played a key role, since 2010 in Rome and Rio de Janeiro, playing a significant role in the Plexus art journey.